FSH’s Role in Tilapia Testis Differentiation #AcademicAchievements
Follicle-stimulating hormone (FSH) is classically known for its functions in gametogenesis and supporting Sertoli cell activity, but its involvement in early testis differentiation in Nile tilapia (Oreochromis niloticus) has recently drawn attention. In tilapia, sex determination follows an XX/XY system, and the transition of undifferentiated gonads into testes in genetic males involves tightly regulated gene networks and steroid biosynthesis pathways. In the published study “The Involvement of Follicle-Stimulating Hormone in Testis Differentiation in Nile Tilapia,” the authors explored whether FSH signaling contributes to the initiation or modulation of testis‐specific pathways in early larval stages. Their investigations combined microinjection of recombinant tilapia FSH (rFsh) during critical windows of sex differentiation and subsequent expression analysis of key genes tied to steroidogenesis and male fate determination. ...
